Remodelin hydrobromide Chemical Structure
CAS No. : 1622921-15-6
Remodelin 是特異性的(de) N-乙酰基轉移酶 NAT10 的(de)特異性抑制劑，能改善 Hutchinson-Gilford 早衰綜合征細胞表型。Remodelin 通過靶向和(hé)抑制 NAT10，在一(yī)個不依賴于 progerin 和(hé) FTI 的(de)途徑中發揮作用。NAT10 是一(yī)種具有(yǒu)組蛋白乙酰化活性的(de)蛋白質，主要參與端粒酶活性的(de)調節。
| 規格 | 10 mg/支 |
| 貨号 | GM-2022133 |
| 生物活性 | Remodelin, a specific inhibitor of N-acetyltransferase NAT10, can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10[1]. NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity[2]. |
| 體外研究 (In Vivo) | Remodelin blocks invasion and migration of HCC cells in hypoxic conditions[3] We has not independently confirmed the accuracy of these methods. They are for reference only. |
| 體內(nèi)研究 (In Vivo) | Remodelin (100 mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model[1]. We has not independently confirmed the accuracy of these methods. They are for reference only. |
| Animal Model: LmnaG609G/G609G mice (HGPS mice)[1] | |
| Dosage:100 mg/kg | |
| Administration: P.o; daily schedule from 3 weeks of age onward, until the end-point (individual weight maxima) | |
| Result: Well-tolerated by both genotypes, with no weight loss. | |
| 分子(zǐ)量 | 363.28 |
| Formula | C₁₅H₁₅BrN₄S |
| CAS 号 | 1622921-15-6 |
| 運輸條件 | Room temperature in continental US; may vary elsewhere. |
| 儲存方式 | Powder -20°C 3 years |
| 4°C 2 years | |
| In solvent -80°C 6 months | |
| -20°C 1 month |
參考文獻
| [1]. Balmus G, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9(1):1700. Published 2018 Apr 27. | |
| [2]. Liu H, et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. Mol Cell Biochem. 2007;300(1-2):249-258. | |
| [3]. Ma R, et al. Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition. Am J Transl Res. 2016;8(10):4215-4223. Published 2016 Oct 15. |
