産品信息
| 規格 | 100μg/支 |
| 貨号 | Gab-202205 |
| 反應物種 | Human, Mouse, Rat |
| 産品應用 | WBIHCIFIP |
| 推薦稀釋比 | WB 1:500 - 1:2000 |
| IHC 1:50 - 1:200 | |
| IF 1:50 - 1:200 | |
| IP 1:50 - 1:200 | |
| 理(lǐ)論分子(zǐ)量 | 52kDa |
| 實際分子(zǐ)量 | 60KDa |
| 存儲緩沖液 | Store at -20℃. Avoid freeze / thaw cycles. |
| Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. | |
| 陽性樣本 | A-549,Raji,Mouse brain,Rat brain |
| 細胞定位 | Nucleus |
| 純化方式 | Affinity purification |
抗原信息
靶點背景信息
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A, which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity. In embryonic stem cells (ESCs, m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity.
| RRID | AB_2715536 |
| 基因ID | 57721 |
| Swiss Prot | Q9HCE5 |
| 别名 | METTL14;hMETTL14 |
